Abstract
Hydrogenation of disubstituted aromatic rings can be achieved under mild reaction conditions in a two-phase system in presence of RhCl 3 and phase transfer agents such as trioctylamine. The catalytic system was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation. A high chemoselectivity and a high stereoselectivity to the Z isomer are obtained. Moreover enantioselective reductions of o-cresol derivatives were performed with colloidal rhodium stabilized and modified by chiral amines. Diastereoselective reductions were also obtained using chiral auxiliaries bound to the substrate.
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