Abstract
Substituted ( S)-1-phenyl- 2a– h and ( S)-1-benzyl-propan-2-ols 4a and b, and ( S)-1-phenylethanol 6 were produced from prochiral ketones 1a– h, 3a, b and 5 by reductions with freshly harvested Zygosaccharomyces rouxii and Debaryomyces hansenii cells. The bioreductions were also performed by lyophilized cells. Comparison of the secondary alcohols from the bioreductions 2b– e, g, h and 4a and authentic ( S)-alcohols ( S)- 2b– e, g, h and ( S)- 4a synthesized from enantiopure ( S)-methyloxirane 7 proved the absolute configuration of the products.
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