Abstract
AbstractEthyl secodione (1) has been enantioselectively reduced by using different biocatalysts for the preparation of ethyl secol (13R, 17S)‐2a. The recombinant ketoreductase KRED1‐Pglu converted the substrate with the highest reaction rate and stereoselectivity (ee > 98 %), whereas whole cells of Pichia minuta CBS 1708 showed the highest productivity. Stereoselective reduction of 1 provides the key chiral precursor for the synthesis of a number of hormonal contraceptives (i.e., desogestrel, norgestrel, gestodene).
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