Abstract
The enantioselective separation of omeprazole on different chiral stationary phases was investigated. The two enantiomers could be resolved on three different phases with immobilized protein, Chiral-AGP, Ultron ES-OVM and BSA-DSC, employing aqueous mobile phases with 2-propanol as organic modifier. On Chiralpak AD, an amylose-based chiral stationary phase, the enantiomers of omeprazole and three analogues could be separated using a non-polar hexane-ethanol mobile phase. For omeprazole the retention order was reversed when 2-propanol was replaced with ethanol or methanol as the modifier of hexane in the mobile phase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.