Abstract
Stereoselective construction of steroidal side chain at C-20 having ‘natural’ configuration using 16-dehydropregnalone acetate (16-DPA) as a starting material has been carried out. Palladium-catalyzed carbon-carbon bond-forming Heck reaction between C-20 vinyl iodide with methyl acrylate and transfer hydrogenation with triethylsilane and Pd/C are the key steps for stereoselective side-chain synthesis.
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