Abstract
The effects of 5-HT1A receptor agonist 8-OH-DPAT were compared with those of the mixed β-adrenoceptor and 5-HT 1 a receptor antagonist ( − )pindolol, and the selective β-adrenoceptor antagonist betaxolol in rats implanted for chronic sleep recordings, 8-OH-DPAT (0.375 mg kg ) significantly increased wakefulness and decreased slow wave sleep (SWS) and REM sleep (REMS). At 2.0–4.0 mg kg ( − )pindolol reduced REMS. Betaxolol in doses of 1.0 and 2.0 mg kg did not significantly modify sleep variables. Pretreatment with ( − )pindolol (2.0–4.0 mg kg ) reversed the effect of 8-OH-DPAT on waking and SWS, while (+)pindolol (4.0 mg kg ) and betaxolol (2.0 mg kg ) were ineffective in this respect. The Stereoselective antagonism by the pindolol enantiomers supports the proposal that 8-OH-DPAT-induced increase of waking and decrease of SWS depends on the activation of 5-HT 1 a receptors. The absence of antagonism by betaxolol tends to indicate that prevention by ( − )pindolol of waking increase did not involve β-adrenoceptors.
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