Abstract
To address the role of sulfur in the telomerase–primer recognition process, we investigated the effects of substitution of natural phosphodiester linked DNA telomerase substrates with phosphorothioate group-containing counterparts. Model dodecanucleotides with either stereorandom or stereopure all-Rp/Sp internucleoside phosphorothioate linkages were evaluated and the stereorandom models found to have slightly reduced affinity for the enzyme.
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