Abstract
BackgroundWe conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well as whether stereopsis impairment is associated with motor dysfunction in patients with Parkinson’s disease (PD).MethodOur present study included 45 PD patients and 50 non-PD control patients attending the Movement Disorder Center at Xuanwu Hospital Capital Medical University in Beijing from July 2011 to November 2011. Neurologic evaluations and visual function assessments were conducted, and the results between two groups of patients were compared.ResultsWe found that the total error scores (TESs) and partial error scores (PESs) for red, green, blue and purple were all significantly higher in PD patients than in control patients. The limited grade on the FLY Stereo Acuity Test with LEA Symbols was significantly lower in PD patients than in control patients (P = 0.0001), whereas the percentage of abnormal stereopsis in PD patients was significantly higher than in control patients (42.2% vs. 12%; P = 0.001). Multiple linear regression analysis showed that PD patients with higher Hoehn and Yahr Scale stage, and those with decreased stereopsis had higher Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores and worse motor function. Furthermore, our study demonstrates that the UPDRS motor scores and total average number of the Purdue Pegboard Test scores of PD patients were significantly improved when they had taken their medications, and the TESs and PESs for green were lower in when they were off their medications.ConclusionOur results provide more information on the underlying mechanisms of vision, motor and stereopsis impairments in PD patients.
Highlights
We conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well as whether stereopsis impairment is associated with motor dysfunction in patients with Parkinson’s disease (PD)
The mean total average number (TAN) (PPT scores) in PD patients was 34.28 ± 10.12, which is significantly lower than the mean score of 49.56 ± 6.50 in controls (P = 0.0001)
Our results show that limited grade (LG) values on the FLY Stereo Acuity Test with LEA Symbols (P = 0.008) and Hoehn and Yahr (H&Y) stage (P = 0.018) were independently associated with Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores
Summary
We conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well as whether stereopsis impairment is associated with motor dysfunction in patients with Parkinson’s disease (PD). The impairment in color discrimination is one of the most well-established visual deficits in PD patients [1,2,3]. It can be caused by peripheral retinal dopaminergic deficiency [4,5,6] or by central visual impairments such as orientation impairments [7,8], motion detection deficit [9,10] and abnormal visual attention [11,12]. Because color perception can be improved with levodopa therapy, we tested whether this treatment can improve stereopsis dysfunction
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