Abstract
BackgroundThe purpose of this study was to test the stereology method using several grid sizes for measuring liver volume and to find which grid provides an accurate estimate of liver volume.Materials and methodsLiver volume was measured by volumetry in 41 sets of liver MRI. MRI was performed before and after different weight-reducing regimens. Grids of 3, 4, 5, and 6 cm were used to measure liver volume on different occasions by stereology. The liver volume and the changes in volume before and after treatment were compared between stereology and volumetry.ResultsThere was no significant difference in measurements between stereology methods and volumetry (p > 0.05). The mean differences in liver volume between stereology based on 3-, 4-, 5-, and 6-cm grids and volumetry were 37, 3, 132, and 23 mL, respectively, and the differences in measurement of liver volume change were 21, 2, 19, and 76 mL, respectively. The mean time required for measurement by stereology was 59–190 s.ConclusionStereology employing 3- and 4-cm grids can rapidly provide accurate results for measuring liver volume and changes in liver volume.Main Messages• Statistical methods can be used for measuring area/volume in radiology.• Measuring liver volume by stereology by 4-cm grids can be done in less than two minutes.• Follow-up of liver volume is highly accurate with stereological methods.
Highlights
The purpose of this study was to test the stereology method using several grid sizes for measuring liver volume and to find which grid provides an accurate estimate of liver volume
The average liver volume measured on volumetry was 1,998 Mean LV ± SD (mL) with a standard deviation (SD) of 319 mL
The 3- and 4-cm grids provided measurement results that differed from the volumetric measurements by less than 300 mL
Summary
The purpose of this study was to test the stereology method using several grid sizes for measuring liver volume and to find which grid provides an accurate estimate of liver volume. Materials and methods Liver volume was measured by volumetry in 41 sets of liver MRI. Grids of 3, 4, 5, and 6 cm were used to measure liver volume on different occasions by stereology. Liver volume can be of prognostic value prior to liver surgery in certain patients [1, 2]. This is one of the many reasons that liver volume measurement has attracted much attention, with more than 200 results in PubMed when searching for “liver volumetry.”. Knowledge of attenuation on CT is very helpful for delineating the liver in semi-automated programs. Measurement of attenuation is not possible on magnetic resonance imaging (MRI) [4] and its different sequences
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