Stereologic analysis of ultrastructural changes in cardiomyocytes in adriblastine-induced cardiomyopathy

Abstract

Both single and graded administration of an anthracycline antibiotic adriablastine at a dose of 20 mg/kg to white rats have resulted in cardiomyocyte volume decrease, dystrophia and lysis of myofibrils, and reduction of mitochondrial surface density volume. Accumulations of myelin bodies of different configuration and diffuse myolysis were observed. Myelin bodies and diffuse myolysis of cardiomyocytes in adriablastine-induced cardiomyopathy are believed to be a morphological sign of lipid peroxidation.