Abstract

AbstractAn efficient synthetic route to the C1‐C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn‐aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti‐aldol reaction for C3 and C4, the Tishchenko–Evans reaction for C5, and a chiral building block for C2.

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