Stereocontrolled synthesis of spirocyclopropane sugars and their application to asymmetric formation of tertiary chiral centres: A route to 2,2′-dialkylated pyranose subunit (C 18C 23) of lasonolide A

Abstract

A novel route to asymmetric formation of tertiary chiral centres of sugars via 2,2′- spirocyclopropane derivatives has been described. This route forms the basis of our proposed synthesis of the C 18C 23 subunit of lasonolide A.