Abstract
The stereocontrolled synthesis of amino hydroxyalkyl diphenylphosphine oxides has been achieved starting from (2 S,3 S)- N, N-dibenzyl-3-hydroxy-2-methylazetidinium bromide or (1 R),[1′( S)-(dibenzylamino)ethyl]oxirane. The regioselective ring opening of both heterocyclic systems at the less substituted carbon atom with phosphorus nucleophiles proceeded with full stereochemical integrity.
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