Stereocomplexation of Poly(Lactic acid) and Chemical Crosslinking of Ethylene Glycol Dimethacrylate (EGDMA) Double-Crosslinked Temperature/pH Dual Responsive Hydrogels.

Zhidan Wang,Wenli Gao,Fei Song,Xiaoyu Shi,Jie Wu,Shouxin Liu

doi:10.3390/polym12102204

Zhidan Wang, Wenli Gao + Show 4 more

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https://doi.org/10.3390/polym12102204

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Journal: Polymers	Publication Date: Sep 25, 2020
Citations: 12	License type: CC BY 4.0

Affiliation: Shaanxi Normal University

Abstract

Physical crosslinking and chemical crosslinking were used to further improve the mechanical properties and stability of the gel. A temperature/pH dual sensitive and double-crosslinked gel was prepared by the stereo-complex of HEMA-PLLA20 and HEMA-PDLA20 as a physical crosslinking agent, ethylene glycol dimethacrylate (EGDMA) as a chemical crosslinking agent, and azodiisobutyronitrile (AIBN) as an initiator for free radical polymerization. This paper focused on the performance comparison of chemical crosslinked gel, a physical crosslinked gel, and a dual crosslinked gel. The water absorption, temperature, and pH sensitivity of the three hydrogels were studied by a scanning electron microscope (SEM) and swelling performance research. We used a thermal analysis system (TGA) and dynamic viscoelastic spectrometer to study thermal properties and mechanical properties of these gels. Lastly, the in vitro drug release behavior of double-crosslinked hydrogel loaded with doxorubicin under different conditions was studied. The results show that the double-crosslinked and temperature/pH dual responsive hydrogels has great mechanical properties and good stability.

Highlights

Among the treatment approaches for many diseases, the oral route is one of the safest and promising ways to deliver drugs effectively [1,2]
In order to improve the mechanical properties of hydrogels, many new hydrogel materials have been widely studied such as the topological gel (TP gel) [18], dual-crosslinked hydrogels (DN gel) [19], and nanocomposite gels (NC gel) [20]
The poly-based double crosslinked hydrogel was synthesized by the stereo-complex microcrystal formed between PLLA and PDLA as the physical crosslinking and agent ethylene glycol dimethacrylate (EGDMA) as chemical crosslinking

Summary

Introduction

Among the treatment approaches for many diseases, the oral route is one of the safest and promising ways to deliver drugs effectively [1,2]. As a drug carrier with good biocompatibility and strong practicability, the hydrogel has been widely applied in the field of medicine delivery in recent years [3,4]. The study of stimuli-responsive hydrogels has further improved the targeted release of drug-loaded hydrogels and expanded the application of hydrogels. The poor mechanical properties of hydrogels have always been one of the obstacles hindering its development in the medical field [16,17]. In order to improve the mechanical properties of hydrogels, many new hydrogel materials have been widely studied such as the topological gel (TP gel) [18], dual-crosslinked hydrogels (DN gel) [19], and nanocomposite gels (NC gel) [20]

Methods

Results

Conclusion