Stereochemistry of the bucherer‐bergs reaction and a modified strecker reaction on tetrahydro‐2H‐pyran‐3‐ones

Abstract

AbstractThe stereochemical aspects of the Bucherer‐Bergs reaction and a modified Strecker reaction on tetrahydro‐2H‐pyran‐3‐one derivatives have been studied in details through the use of several nmr techniques. It was found that, in both reactions, the orientation of the substituents introduced on C‐3 of the pyran ring, depends from the number and nature of the substituents on the neighbouring C‐2 atom.