Stereochemistry of Gd 3+ and Mn 2+ interactions with D-gluconamide derivatives by 13C NMR spectroscopy

Abstract

Natural abundance 13C nuclear magnetic resonance spectroscopy ( 13C NMR) was used to study the mode of binding of Gd 3+ and Mn 2+ to the polyol portion of several synthetic D-gluconamides. The results indicate that Gd 3+ forms a single, unique binding structure requiring three oxygen atoms. The binding of Mn 2+ to the polyol portion of these compounds appears to be nonspecific. The carbohydrate containing model compounds studied may be used to design new metal-ion chelating agents.