Abstract

The absolute configuration of mercaptosuccinic acid was unequivocally determined by its chemical correlation with glyceraldehyde via (-) N-acetyl-4-allomercapto-L-proline thiol-lactone ((-) XI), as shown in Chart 2 and Chart 3. It becomes clear that mercaptosuccinic acid, with a positive rotation in water, belongs to the R-series. Our results show that Fredga's proposal, based on the method of quasi-racemate formation, is correct.This method of configurational correlation is unique since chemical correlation was performed without replacing the C-S bond with the C-O bond.

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