Abstract
GC/MS/MS techniques to quantitate mixtures of acyclic stereoisomers are explored for a set of secondary n-alkyl phenyl ethers vicinally substituted with deuterium. Examination of a set of test compounds using a commercial quadrupole ion trap instrument (GC/QIT) reveals large differences between threo and erythro diastereomers when trapped molecular ions expel neutral alkene as a result of collisionally activated dissociation (CAD). All of the monodeuterated compounds give PhOH•+ (m/z 94) and PhOD•+ (m/z 95) as the principal fragments under GC/QIT/CAD conditions. The threo isomers give consistently larger values of the ion intensity ratio r = m/z 95/m/z 94 than do the corresponding erythro, with a ratio of ratios rt/re as high as 3. A nonlinear calibration curve shows that the threo decomposes to a lesser extent than the erythro in mixtures of the two stereoisomers; hence, the precision of quantitation is sensitive to experimental error. Sustained off-resonance irradiation experiments in an FT-ICR give vir...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
