Abstract
A new cyclic depsipeptide stereocalpin A ( 1) has been isolated from the MeOH extract of the Antarctic lichen Stereocaulon alpinum by various chromatographic methods. The structure of stereocalpin A ( 1) was mainly determined by analysis of the NMR spectroscopic data and by chemical methods. Stereocalpin A ( 1) is a unique cyclic peptide incorporating an unprecedented 5-hydroxy-2,4-dimethyl-3-oxo-octanoic acid in the structure. Stereocalpin A ( 1) shows moderate cytotoxicity against three human solid tumor cell lines.
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