Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury.

Ce Yang,Jianxin Jiang,Juan Du,Xuetao Yang,Haiyan Wang

doi:10.1186/s12967-016-0804-1

Ce Yang, Jianxin Jiang + Show 3 more

Open Access

https://doi.org/10.1186/s12967-016-0804-1

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Abstract

The repair of organs and tissues has stepped into a prospective era of regenerative medicine. However, basic research and clinical practice in the lung regeneration remains crawling. Owing to the complicated three dimensional structures and above 40 types of pulmonary cells, the regeneration of lung tissues becomes a great challenge. Compelling evidence has showed that distinct populations of intrapulmonary and extrapulmonary stem/progenitor cells can regenerate epithelia as well as endothelia in various parts of the respiratory tract. Recently, the discovery of human lung stem cells and their relevant studies has opened the door of hope again, which might put us on the path to repair our injured body parts, lungs on demand. Herein, we emphasized the role of endogenous and exogenous stem/progenitor cells in lungs as well as artificial tissue repair for the injured lungs, which constitute a marvelous toolbox for the treatment of acute lung injury. Finally, we further discussed the potential problems in the pulmonary remodeling and regeneration.

Highlights

With the occurrence and evolution of critical diseases (trauma, burn, infections, sepsis, hemorrhagic shock), lungs belong to the most injured organs
With the occurrence and evolution of critical diseases, lungs belong to the most injured organs
Concerning the protective roles of bone marrow- and peripheral blood-derived epithelial progenitor cells (EPCs) in Acute lung injury (ALI), recent studies showed that their peripheral infusion could lead to homing in injured lung tissues [24], relieving the inflammatory injury [25, 26] and promote the endothelial repair and recovery of immune function dissonance [26, 27], which may be enhanced by the treatment of simvastatin [28]

Summary

Introduction

With the occurrence and evolution of critical diseases (trauma, burn, infections, sepsis, hemorrhagic shock), lungs belong to the most injured organs. Concerning the protective roles of bone marrow- and peripheral blood-derived EPCs in ALI, recent studies showed that their peripheral infusion could lead to homing in injured lung tissues [24], relieving the inflammatory injury [25, 26] and promote the endothelial repair and recovery of immune function dissonance [26, 27], which may be enhanced by the treatment of simvastatin [28].

Results

Conclusion