Abstract
Degeneration of dopaminergic nigrostriatal neurons results in the progressive development of Parkinson's disease (PD). Considerable progress has been made in creating dopamine-producing cells from stem cells. However, a major barrier in this area of research is the lack of progressive and predictive cell models of PD. Despite the fact that stem cells can provide a valuable option for the treatment of PD and related disorders, there are many challenges associated with their use. Although it is promising that stem cells can regenerate dopaminergic neurons and overcome the functional deficiency of dopamine, risk factors associated with them cannot be neglected. Stem cells can not only serve as a treatment option for PD, but their derivatives can also serve as cell models for PD, and can be used to study the molecular and neurochemical mechanisms involved in the pathophysiology of the PD, in vivo .
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