Abstract
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention. Herein, we highlight alternative therapeutics for OA specifically considering innovative and encouraging translational methods with the use of adipose mesenchymal stem cells.
Highlights
Published: 22 September 2021Osteoarthritis (OA) is a chronic disease caused by biomechanical deterioration of the joint, cell stress and extracellular matrix degeneration due to injury and dysfunctional repair mechanisms involving the activation of pro-inflammatory processes of innate immunity [1]
Numerous recommendation for osteoarthritis diagnosis have been developed, such as biomarkers to expect both biological activities as natural disease progression
Studies have assessed the efficacy of novel treatment options such as intra-articular applications of corticosteroid injections, hyaluronic acid injections, platelet-rich plasma (PRP) or autologous micro-fragmented adipose tissue with stromal vascular fraction for secondary prevention [9,10,11]
Summary
Osteoarthritis (OA) is a chronic disease caused by biomechanical deterioration of the joint, cell stress and extracellular matrix degeneration due to injury and dysfunctional repair mechanisms involving the activation of pro-inflammatory processes of innate immunity [1]. Numerous recommendation for osteoarthritis diagnosis have been developed, such as biomarkers to expect both biological activities as natural disease progression, . Prevention of the progression of OA still remains an enigma, but novel biological therapies have been investigated in an effort to decelerate disease development during the early phase of asymptomatic OA towards a change in the evolution of the disease. Studies have assessed the efficacy of novel treatment options such as intra-articular applications of corticosteroid injections, hyaluronic acid injections, platelet-rich plasma (PRP) or autologous micro-fragmented adipose tissue with stromal vascular fraction for secondary prevention [9,10,11].
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