Abstract
During normal mammalian hair growth, hair follicles undergo phases of growth, regression, and rest throughout the life of the animal. At the onset of the growth phase, cells recruited from the hair bulge form a hair germ, from which a new hair bulb develops. The adult hair bulge harbors keratinocyte cells, some of which are capable of clonal growth in cell culture, which may represent progenitor cells that underlie the formation of different hair follicle cell lineages or may be multipotent stem cells that can sustain long-term hair follicle renewal.
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