Abstract
Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes?
Highlights
The discovery of insulin more than 90 years ago transformed T1D from a fatal disease to a manageable condition
⁎ Corresponding author at: Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Another potential source of beta cells that could be used in diabetes treatment are embryonic stem cells
Baetge and colleagues reported preliminary success at beta cell differentiation — they showed that exposing embryonic stem cells to a series of molecules participating in pancreatic development gave rise to insulin-producing cells in vitro (D'Amour et al, 2006)
Summary
The discovery of insulin more than 90 years ago transformed T1D from a fatal disease to a manageable condition. Another potential source of beta cells that could be used in diabetes treatment are embryonic stem cells. Remarkably, when these immature cells were transplanted into mice, mature beta cells formed — cells that could maintain normal glucose levels after ablation of the mouse's intrinsic pancreatic beta cells (Kroon et al, 2008).
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