Abstract
Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models.
Highlights
Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable
A review of current therapies indicates that bisphosphonates, anti-receptor activator of NF-kb ligand, and anti-sclerostin antibodies are used to counter osteoporosis
We showed that IBM-bone marrow transplantation (BMT) combined with Co (III) Protoporphyrin IX Chloride, which
Summary
Reviewed by: Maria Luisa Cayuela, Hospital Clinico Universitario Virgen de la Arrixaca, Spain Maria Caterina Mione, Karlsruhe Institute of Technology, Germany. Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer’s disease (AD), Parkinson’s disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models
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