Abstract
Many human diseases relating to central nervous system (CNS) are mimicked in animal models to evaluate the efficacy of stem cell therapy. The therapeutic role of stem cells in animal models of CNS diseases include replacement of diseased or degenerated neuron, oligodendrocytes and astrocytes with healthy ones, secretion of neurotrophic factors and delivery of therapeutics/genes. Scaffolds can be utilized for delivering stem cells in brain. Sustained delivery of stem cells, lineage specific differentiation, and enhanced neuronal network integration are the hallmarks of scaffold mediated stem cell delivery in CNS diseases. This review discusses the therapeutic role, challenges and future perspectives of stem cell therapy in animal models of CNS diseases.
Highlights
Treatment of central nervous system (CNS) injuries had been a challenge for medical and veterinary clinicians. It was in the naïve stage until early 20th century (Schmidt and Leach, 2003) as the recovery in CNS is limited by the insufficient self–repair and regeneration abilities of the brain tissues (Bjorklund and Lindvall, 2000)
Low et al (2013), investigated the possibility of scaffold mediated gene silencing by delivering small interfering RNA/ transfection agent complexes via mussel– inspired polydopamine modified electrospun polycaprolactone nanofibre scaffolds and concluded that it could be a future promise for therapy as enhanced neuronal commitment of primary mouse neural progenitor cells and decreased glial cell differentiation was seen
The therapeutic effects of stem cells in animal models of CNS diseases are discussed in this review
Summary
Treatment of central nervous system (CNS) injuries had been a challenge for medical and veterinary clinicians. Cell replacement, Challenges, CNS diseases, Scaffold, Stem cell therapy
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