Abstract
Stem cell rejuvenation increases health- and lifespan Cancer is a disease of the elderly, and chemotherapy remains the mainstay of treatment. Unfortunately, older patients are highly susceptible to specific toxicities of chemotherapy, like myelosuppression and life-threatening neutropenia. ReSinAge explores the possibility of improving the regenerative capacity of the aged stem cell niche as an unprecedented, innovative strategy to improve the haematopoietic recovery and increase the survival after chemotherapy in the elderly. More broadly, we aim to provide proof-of-concept evidence that increasing the regenerative potential of endogenous aged somatic stem cells represents an important strategy for rejuvenating tissues and improving health- and lifespan in the elderly.
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