Abstract

Determined stem cells for liver and pancreas are present in stem cell niches, peribiliary glands (PBGs), throughout the biliary tree. PBGs are connected to intrahepatic stem cell niches, canals of Hering, and niches of committed progenitors, pancreatic duct glands. The phenotypic traits in the most primitive populations comprise both liver and pancreatic markers (transcription factors, pluripotency genes, endodermal genes), and their highest numbers are in large intrahepatic bile ducts and the hepato-pancreatic common duct. Their descendants have phenotypic traits implicating maturational lineages along a radial axis within bile duct walls and a proximal-to-distal axis from duodenum to mature cells near or in the liver or pancreas. The stem cells and lineages constitute a biological framework for hepatic and pancreatic organogenesis throughout life.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.