Stem Cell Microenvironment as a Potential Therapeutic Target

Abstract

Regenerative MedicineVol. 7, No. 1 EditorialStem cell microenvironment as a potential therapeutic targetCharles C Lee & Kee D KimCharles C LeeMolecular Matrix, Inc. and University of California, Davis, CA, USASearch for more papers by this author & Kee D Kim* Author for correspondenceDepartment of Neurological Surgery, Davis School of Medicine, University of California, Sacramento, CA 95817, USA. Search for more papers by this authorEmail the corresponding author at kdkim@ucdavis.eduPublished Online:15 Dec 2011https://doi.org/10.2217/rme.11.104AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: injurymicroenvironmentnicherepairstem cellReferences1 Yoon YS, Lee N, Scadova H. Myocardial regeneration with bone-marrow-derived stem cells. Biol. Cell.97,253–263 (2005).Crossref, Medline, CAS, Google Scholar2 Sadat S, Gehmert S, Song YH et al. The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem. Biophys. Res. Commun.363,674–679 (2007).Crossref, Medline, CAS, Google Scholar3 Corti S, Locatelli F, Donadoni C et al. Neuroectodermal and microglial differentiation of bone marrow cells in the mouse spinal cord and sensory ganglia. J. Neurosci. Res.70,721–733 (2002).Crossref, Medline, CAS, Google Scholar4 Wright KT, El Masri W, Osman A, Chowdhury J, Johnson WE. Concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells29,169–178 (2011).Crossref, Medline, CAS, Google Scholar5 Xue X, Pech NK, Shelley WC, Srour EF, Yoder MC, Dinauer MC. Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice. Blood116,5419–5422 (2010).Crossref, Medline, CAS, Google Scholar6 Davis ME, Hsieh PC, Grodzinsky AJ, Lee RT. Custom design of the cardiac microenvironment with biomaterials. Circ. Res.97,8–15 (2005).Crossref, Medline, CAS, Google Scholar7 LaBarge MA, Nelson CM, Villadsen R et al. Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol. (Cambridge)1,70–79 (2009).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByBiologics: Inherent Challenges1 April 2021Biologics: Inherent Challenges22 August 2020Stem and progenitor cell microenvironment for bone regeneration and repairCharles C Lee, Naoki Hirasawa, Katrina G Garcia, Dinesh Ramanathan & Kee D Kim8 August 2019 | Regenerative Medicine, Vol. 14, No. 7Laminin-511 Supplementation Enhances Stem Cell Localization With Suppression in the Decline of Cardiac Function in Acute Infarct RatsTransplantation, Vol. 103, No. 5Stem Cells and Discogenic Low Back PainSPINE, Vol. 41Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond12 January 2013 | Cell Biochemistry and Function, Vol. 31, No. 4 Vol. 7, No. 1 Follow us on social media for the latest updates Metrics Downloaded 994 times History Published online 15 December 2011 Published in print January 2012 Information© Future Medicine LtdKeywordsinjurymicroenvironmentnicherepairstem cellFinancial & competing interests disclosureCC Lee is currently a chief executive officer of Molecular Matrix, Inc., which may use stem cells for therapeutic applications. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download