Abstract
One of the cancer prevention measures involves the correctionof the altered functions of the body’s regulatory systems. Manymalignant tumors are accompanied by the thyroid system dysfunction.The aim of our study was to reveal an effect of an iodine-containingdrug on the development of a tumor process in thelungs and the level of thyroid hormones in blood and the thyroidgland in male rats.Material and methods. Outbred white male rats were dividedinto the following groups: a group of intact animals (n=7); acomparison group – 5 weeks after an intravenous inoculationof sarcoma 45 (S45) at 2*106 (n=7); a main group – 5 weeks afteran intravenous inoculation of S45 and intragastric administrationof Stellanin at a single dose of 0.4 mg/kg within an hourafter the inoculation (n=10). RIA was used to determine levels offree (F) and total triiodothyronine (T3) and thyroxine (T4) in theblood serum and the thyroid.Results. The lungs of rats in the comparison group were totallyaffected by the tumor, and the thyroid gland showed asharp decrease in the levels of all hormone forms: T4 – by 18.7times, T3 – by 8.5 times, FТ4 – by 8.1 times, FТ3 – by 21.3 times,while only FТ4 and FТ3 decreased in blood by 2.5 and 1.5 times,respectively (p<0.05). No tumor lesions were detected in thelungs of rats of the main group, and the hormone levels exceededthe levels in the comparison group: in the thyroid, FT4by 3.7, T4 by 15.0 and T3 by 6.0 times; in blood, FT4 by 3.3 andFT3 by 1.7 times.Conclusions. The effect of Stellanin inhibiting malignantgrowth of S45 in the lungs is accompanied by the restoration oflow levels of thyroid hormones in the thyroid and blood.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
