STEATOUS CHANGES IN HEPATOCYTES IN PATIENTS WITH CHRONIC HEPATITIS C

Abstract

Background. The main consequences of progressing of a chronic hepatitis C are a cirrhosis of a liver and hepatocellular carcinoma. Considering that for last years number of cases of CHC disease among population of the world has essentially increased, creation of adequate methods of an estimation of morphological and metabolic shifts in a liver tissue at CHC is the important clinical problem.
 Aim: to determine the morphological features of steatosis in patients with CHC and assess its effect on the progression of hepatitis.
 Materials and methods. Under supervision there were 46 CHC patients in the age of 19 - 66 years, 36 men and 10 - women. Liver biopsy was carried out under the control of ultrasonic research with local anesthesia.
 Conclusion. Among CHC patients steatosis of a liver is observed in 60, 9% of supervised. Expressiveness of steatosis on Hornboll is distributed: 1-st degree at 13,0% of patients, 2-nd – 28,3%, 3-rd – 19,6%, absence of steatosis- at 39,1%. At initial stages of steatosis in hepatocytes of peripheral zone of segments the significant amount lysosomes, which look like lipofuscin granules which contain lipide, electronically-dense, small-sized granular, pigmentary component, safety of structure of organelles, hyperplasia mitochondrions. At expressed steatosis dense lipid vacuoles which borrow the most part of cytoplasm of hepatocytes, displace organelles, deform a kernel of cells, damage superficial membranes mitochondrions are observed. In periportal zone, on border of contact of hepatocytes which contain lipid granules, and lymphomonocytic infiltrate, the expressed activation of Kupfer cells, insufficiency of granules in cells of ITO, their transformation in fibroblasts, the expressed adjournment of collagenic fibers is observed.