Abstract
Introduction: Hypertensive disorders of pregnancy (HDP) are the most common complications observed during pregnancy and are a leading cause of maternal and perinatal morbidity and mortality. Thyroid hormone abnormalities are prevalent in females of reproductive age group. However, the relation between thyroid hormones and hypertensive pregnant women remains unclear. This study aims to assess the status of thyroid hormone abnormalities in patients with HDP.
 Materials and Methods: This is a case-control study conducted for one year in Karnali Province Hospital and Deuti Hospital, Surkhet, Nepal. Thirty hypertensive patients with singleton pregnancies in the third trimester were taken as case and 30 healthy normotensive singleton pregnant women as control and their thyroid hormone parameters were compared. Statistical analysis was done using SPSS version 21.
 Results: The mean gestational age of recruited study subjects and control were 37.00 ± 3.04 weeks and 35.70±3.83 weeks (p>0.05). The mean value of TSH was significantly higher (p<0.05) in hypertensive subjects (4.19±2.95) μIU/L when compared with the control (2.67±1.71) μIU/L. There was no significant difference when the serum level of FT3 and FT4 were compared between hypertensive and normotensive pregnant women (p>0.05). Subclinical hypothyroidism was found in 16.66% of hypertensive subjects.
 Conclusions: HDP is associated with thyroid hormone abnormalities. An increase in TSH levels with normal FT3 and FT4 levels were found to be the most common form of thyroid dysfunction during pregnancy.
Highlights
Hypertensive disorders of pregnancy (HDP) are the most common complications observed during pregnancy and are a leading cause of maternal and perinatal morbidity and mortality
HDP is associated with thyroid hormone abnormalities
We found a higher level of thyroid-stimulating hormone (TSH) (4.30±1.35) in mild preeclampsia whereas, in normotensive control, the level of TSH was 2.67±1.71
Summary
Hypertensive disorders of pregnancy (HDP) are the most common complications observed during pregnancy and are a leading cause of maternal and perinatal morbidity and mortality. Thyroid hormone abnormalities are prevalent in females of reproductive age group. This study aims to assess the status of thyroid hormone abnormalities in patients with HDP. Thyroid hormone abnormalities frequently occur during pregnancy and are associated with adverse health outcomes for both mother and child, including increased risk of miscarriage, gestational hypertension, preterm delivery, placental abruption, low birth weight, and fetal death.[6] Both hyper and hypothyroidism can negatively affect the prognosis of pregnancy. The severity of preeclampsia is positively correlated with the level of thyroid-stimulating hormone (TSH).
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