Abstract
The enzyme {gamma}-glutamyl transpeptidase which catalyzes the transfer of glutamyl groups of peptides to other peptides and amino acids, has been proposed as a marker of neoplasia. The high levels of GGT activity have been observed in a variety of neoplastic cells and tissues from several rodent species, and cursory observation suggests that GGT is a marker of cellular proliferation. In the present study, attempt has been made to study the status of GGT activity in mouse skin in response to some well known cutaneous carcinogenic, weakly carcinogenic and non carcinogenic polyaromatic hydrocarbons and tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA), 24 hours after single topical application of these compounds.
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