Status of Interlukin-6 and lipid profile in depression disorder

Abstract

Introduction: Present study was conducted to evaluate the role of interlukin-6 and lipid profile in patients of depression. Materials and Methods: A case-control study consisted of 100 patients and 50 controls, who were attending psychiatric O.P.D in Geetanjali medical college & hospital, Udaipur Rajasthan. Inclusion criteria-depressive subjects those attending psychiatric O.P.D of Geetanjali hospital (20-60yrs). Exclusion criteria- patients undergoing treatment of any other hypertension, diabetes, cardiovascular disorders documented by physical & clinical examination. Level of IL-6 and lipid profile was measured in serum. Analysis was done using SPSS version 16.0 at significant level of 95% confidence level and p-value ?0.005. Results: The mean total cholesterol level in depression patients was 136.08±24.08, mean HDL-c was 41.97±16.50, mean LDL-c was 109.33±21.06, mean triglycerides level was 134.28±16.02 and mean interlukin-6 level was 4.19±1.33. The mean total cholesterol level in controls was 182.3±35.76, mean HDL-c was 51.3±13.08, mean LDL-c was 121.9±25.69, mean triglycerides level was 154.7±24.45 and mean interlukin-6 level was 2.02±0.43. We found that there is a significant negative correlation between interlukin-6, total cholesterol (-0.730) and triglycerides (-0.896). There is significant positive correlation between interlukin-6 and LDL-c (0.977). Conclusion: Depression is undoubtedly a multidimensional disorder. IL-6 exerts a multilayered effect on determinants of behavior, and understanding the role of IL-6 in the pathophysiology of depression may facilitate the elucidation of its effect on alterations in lipid metabolism. Keywords: Cholesterol, Depression, HDL, Interlukin-6, LDL, Triglycerides.