STATUS OF INDICATORS OF PROTEO- AND FIBRINOLYTIC ACTIVITY IN THE LUNGS OF RATS WITH DIABETES COMPLICATED BY ISCHEMIA-REPERFUSION OF THE BRAIN IN THE DYNAMICS OF ITS COURSE

Abstract

The purpose of the work – to investigate the state of proteo- and fibrinolytic activity inthe lungs of rats with type 2 diabetes and under the conditions of its complication by acutecerebral blood circulation in the basin of the carotid arteries.Materials and methods. In rats with four-month-old type 2 diabetes was simulatedbilateral carotid ischemia for 20 min. In lung homogenates, indicators of proteo- andfibrinolytic activity were determined after 1 hour from the beginning of reperfusion andon the 12th day of the postischemic period.The results. In the lungs of rats without diabetes after 20-minute ischemia with one-hourreperfusion, indicators of proteolytic and fibrinolytic activity decrease; on the 12th dayof the postischemic period, the reversion of the reaction to ischemia occurs – during thisperiod, the studied indicators exceed the control values. In rats with diabetes, higherrates of lysis of low- and high-molecular- weight proteins and a lower rate of collagenlysis were found than in animals of the control group. Ischemia- reperfusion of the brainagainst the background of diabetes mellitus reduces the lysis of high molecular weightproteins in the lungs and does not affect the rest of the investigated indicators of proteoand fibrinolytic activity in both periods of observation.Conclusions. 1. Diabetes mellitus increases the lysis of low- and high-molecular proteinsand reduces the lysis of collagen in the lungs of rats. 2. In contrast to rats of the controlgroup, in rats with diabetes, the response of proteo- and fibrinolytic indicators in the lungsto acute circulatory disturbance in the carotid arteries basin is limited by a decrease inthe lysis of high-molecular weight proteins in both periods of observation.