Status of high sensitive C- reactive protein (hs-CRP) in NAFLD obese type-2 diabetic subjects

Abstract

Introduction: Non alcoholic fatty liver disease (NAFLD) is a disease occurring in patients without any significant alcohol consumption. It includes a broad spectrum and advanced forms of liver diseases, from simple steatosis to nonalcoholic steatohepatitis, fibrosis, and cirrhosis and is associated with diabetes mellitus, insulin resistance, obesity, dyslipidemia and metabolic syndrome. The aim of this study is to evaluate the metabolic significance of NAFLD in obese and type-2 diabetic subjects compare to healthy group of individuals and those independent factors associated with NAFLD. Materials and Methods: Our study was conducted in Govt. Medial College, Banda (UP) as well as G. R. Medical College, Gwalior (MP). A total of 200 subjects were involved in our study, diagnosis being based on ultrasonography. Out of these, 100 were obese with type-2 diabetic patients and 100 were healthy subjects. They were evaluated by measurement of BMI and several biochemical blood parameters such as fasting blood glucose, lipid profile, liver function tests (ALT, ALP and GGT) and hs-CRP level. Results: An increase in the BMI and levels of FBS, total cholesterol, triglycerides, LDL, VLDL, GGT, ALT, ALP and hs-CRP level and a decrease in HDL was observed in NAFLD group of individuals. The values of these biochemical markers were found higher in NAFLD patients and the variations were found to be statically significant. BMI and triglycerides were positively correlated with fatty liver. Conclusion: Obesity, hyperglycemia, dyslipidemia and increased liver enzymes and hs-CRP level are seen more commonly in non alcoholic fatty liver in type-2 diabetic obese patients. Keywords: NAFLD, BMI, High sensitive C-reactive protein.