Abstract
ABSTRACT We studied the serum concentrations of total testosterone (T), unbound T, dihydrotestosterone (DHT), total estradiol-17β (E2), unbound E2, and luteinizing hormone (LH) in 15 hyperthyroid men with Graves' disease, 4 of whom had gynecomastia. The mean serum T concentration of 1895 ng per 100 ml in hyperthyroid patients was significantly higher than the mean value of 621 in normal men. It could be explained by an increase in serum concentration of sex hormone binding globulin (SHBG) in hyperthyroidism; the mean serum unbound T, 21.9 ng per 100 ml, in hyperthyroid patients was not statistically different from the corresponding value of 17.3 in normal men. Serum DHT concentration was also elevated in hyperthyroid patients. Similarly, the mean serum E2,. 10.8 ng per 100 ml, in hyperthyroid men, was significantly greater than the corresponding mean value of 2.7 in normal men. However, it could not be explained entirely by elevation of serum SHBG in hyperthyroidism. The average unbound E2, concentration,...
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