Status of Antioxidants Molecules and Lipid Peroxidation in the Diabetic Testes

Abstract

Introduction: According to the epidemiological studies, diabetes mellitus has become a potential cause of male infertility. Knowledge regarding how diabetes mellitus interferes with the process of spermatogenesis and results in infertility needs the molecular study in the testis in diabetic condition. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. So, this study was established to investigate the activity of enzymatic antioxidants and oxidative stress in the testis of diabetic model rats. Material & Methods: Diabetes mellitus was induced in the rat by intraperitoneal injection of Streptozotocin. The rats were sacrificed and the dissection was done to take out the testis. The testes were processed for the activity of enzymatic antioxidants. Results: It was found that oxidative stress was increased in the testes of diabetic rats. The sperms were also affected by the chronic hyperglycemia.