STATUS OF A LIVER DETOXING SYSTEM WHEN USING "STARTIN-PHYTO"

Abstract

Enterotoximia in dyspepsia is caused by the microorganisms toxins of microbial association and biogenic amines formed in the intestinal lumen, as a result of a violation of not only cavity, but also parietal digestion. Liver damage when exposed to various toxicants is associated with the metabolism and activity of cytochrome P450, an indicator of the monooxygenase system. In recent decades, the attention of scientists has been receiving the problem of medicinal liver damage. "Startin-phyto" is a combined preparation aimed to removing endogenous intoxication in the treatment of dyspepsia in farm animal young stock. The effect of the drug on monooxygenase and antitoxic liver functions was studied using D.G. Rosin method (1964). It is based on the ability of various chemicals to affect amounts sleep of laboratory rodents (mice, rats) caused by hexenal, which is known to be inactivated in the liver. Five groups of two-month-old female rats were assembled. The animals of the experimental groups (15 animals) have been injected with "Startin-phyto" orally one time at a dose of 6.3 ml / kg. Distilled water for the control group (6 animals) has been used. The general condition of animals was characterized by the biochemical parameters of the blood: the amount of total protein, urea, glucose, total bilirubin, creatinine and the activity of the enzymes aspartate and alanine aminotransferase, lactate dehydrogenase. Total protein was analyzed by biuret reaction; glucose – by the unified glucose oxidase method for orthotolidine oxidation; the creatinine concentration in the blood serum of calves – in according to the Jaffe color reaction unified method; urea – by the urease method. The carried out complex experimental studies have shown that the drug "Startin-phyto", when administered once to rats, enhances detoxification processes in the liver, is safe and does not have a toxic effect on the liver.