Abstract
Neonatal seizures occur with an incidence of 1–5 cases per 1000 live births, and status epilepticus or recurrent seizures are not uncommon patterns. This chapter outlines a definition of neonatal seizures and status epilepticus and describes the newborn’s neurobiologic predisposition to seizures. This is followed by an overview of diverse causes of neonatal seizures ranging from acquired to genetic conditions. We then characterize the clinical semiologies and electrographic features of neonatal status epilepticus, particularly those that are distinct from that in older children and adults. We conclude with a review of appropriate treatments and what is known about the prognosis and outcome following neonatal seizures and status epilepticus.
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