Status epilepticus heralding thymomatous paraneoplastic multifocal cortical encephalitis in Myasthenia Gravis

Abstract

Myasthenia gravis (MG) is an autoimmune disorder involving the neuromuscular junction characterized by fatigable weakness of the striated muscles [1]. It is primarily mediated by autoantibodies against the acetylcholine receptors (AChR) on post-synaptic membrane of the motor end plate and are present in the serum of 85% of MG patients [1]. Recently, antibodies recognizing other skeletal muscle components have been detected which have provide additional diagnostic and prognostic information [2]. Anti-titin antibodies fall under this category and are found in 20–40% of anti-AChR antibody positive patients.