Abstract
<p>Malaria is an infectious disease caused by <em>Plasmodium</em>, which is a single-celled creature that belongs to the group of protozoa. This disease attacks all age groups, both men and women. Malaria can cause death especially in high risk groups namely infants, children under five, pregnant women, besides malaria directly causes anemia and can reduce work productivity. The study design uses a complete randomized design with 4 treatment groups. Group 1 is the control group without any treatment. Group 2 was injected with 1 × 10<sup>2</sup> iRBC. Group 3 is injected with 1 × 10<sup>3</sup> iRBC. Group 4 was injected with 1 × 10<sup>4</sup>. The treatment was given for 30 days. Measurement of body weight was done every day. Examination of the degree of parasitemia was carried out on day 3 after infection with the thin blood smear method. Data measured body weight and degree of parasitemia were analyzed by one way ANOVA and DMRT tests at a significant level of 5%. The results showed a significant difference in body weight between mice infected with parasites versus those not infected. The more doses of parasites that were infected the more it will affect the mice. The conclusion of this research is P. <em>berghei</em> infection gives weight loss effect on balb/c mice.</p><p class="abstrak" align="left"><strong> </strong></p><strong>Keywords:</strong> malaria, <em>Plasmodium berghei</em>, weight
Highlights
Malaria adalah penyakit menular yang disebabkan Plasmodium
The results showed a significant difference in body weight between mice infected with parasites versus those not infected
Increased gastrointestinal permeability in patients with Plasmodium falciparum malaria
Summary
Rancangan penelitian adalah eksperimental menggunakan rancangan acak lengkap (RAL) dengan 4 macam kelompok perlakuan. Setiap perlakuan menggunakan 5 ekor mencit balb/c betina. Kelompok 3 (n=5), di injeksi dengan 1 × 103 iRBC. Kelompok 4 (n=5) di injeksi dengan 1 × 104. Pengukuran bobot tubuh dilakukan dengan menggunakan timbangan hewan. Penimbangan mencit dilakukan setiap hari dan dicatat hasilnya. Pemeriksaan derajat parasitemia dilakukan pada hari ke 3 setelah infeksi. Darah diambil dengan memotong ujung ekor dan selanjutnya diwarnai dengan Giemsa 3%. Data pengukuran kadar berat badan dan derajat parasitemia dianalisis uji one way ANOVA (Analysis Of Variance) untuk melihat perbandingan antar perlakuan dengan taraf signifikan 5%. Jika berpengaruh maka dilanjutkan dengan uji Duncan’s Multiple Range Test (DMRT) pada taraf signifikan 5%
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