Abstract
The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding. Plans are now being developed to provide access to this novel genetic reference population through distribution centers. Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia.
Highlights
The Collaborative Cross (CC) is a mouse genetic reference population conceived 10 years ago as a community resource for systems genetics (Threadgill and Churchill 2012; Threadgill et al 2002)
The genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits
The CC was started with mice from The Jackson Laboratory in three separate locations: the Oak Ridge National Laboratory in Tennessee (Chesler et al 2008), whose population was moved to The University of North Carolina at Chapel Hill; The International Research Livestock Institute in Kenya, whose population was moved to Tel Aviv University in Israel (Iraqi et al 2008); and Western Australian Institute for Medical Research/University of Western Australia/Geniad, Ltd in Perth (Morahan et al 2008)
Summary
This article is published with open access at Springerlink.com
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