Abstract
The current investigation was conducted to maximise the production of the natural anticancer drug from the microbe isolated from the marine soil sample of the Coromandel Coast of the Bay of Bengal region of India. Yellow to red colour pigmented microbes separated by crowd plate method. Bacteria are producing strong colour product subjected to future study. The isolated strains were detected based on biochemical, morphological, and genetic characteristics. Pigment formation was found to be influenced strongly by conditions of the environment. The water-insoluble pigment extracted by acidified methanol and showed maximum absorbance at 535nm. A statistical screening procedure was adopted to select the optimum condition to produce the pigment. The carbon, nitrogen, medium pH, growth condition temperature and revolution of agitation were screened using the response surface methodology statistical model. The near optimum conditions for the production medium were affected by the concentration of peanut, L-proline, percentage inoculum pH and incubation time. When these conditions were employed yield increased as two-fold as the concentration of prodigiosin 789 mg/l.
Highlights
Insertion of biotechnology into the environment of marine which has opened new horizons for locating novel organisms by means of their trapping potential resources
The quantification study indicated that the sample A2 produced relatively more amount of Prodigiosin and this bacterium adapted for the further study
The bacterial strain is having excellent pigment-producing properties adapted for further study
Summary
Insertion of biotechnology into the environment of marine which has opened new horizons for locating novel organisms by means of their trapping potential resources. New chemicals are produced by marine organisms to cope with extreme changes in salinity, pressure and temperature, prevailing in their environment and the substances produced that are special in structural, diverse and functional characteristics. In order to remove drugs from the ocean started the efforts maintained in the late 1960s. Almost 2500 new metabolites from the collection of marine organisms were identified during the period from 1977 to 1987. Studies have shown that the marine ecosystem can be a great source of new chemicals. It is likely that 10,000 compounds remoted from marine species with several new compounds are discovered once a year. Around 300 patents were granted on bioactive marine natural products merchandise among 1969 and 19993
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