Abstract
The volume of cerebral tissue perturbed in experimental models of middle cerebral artery occlusion (MCAO) can be highly variable. Thus, the territories of reduced cerebral blood flow (CBF) or oxygen consumption (CMRO 2) following MCAO might properly be defined using statistical parametric mapping within a population. In order to establish such a method, we mapped CBF and CMRO 2 in 18 pigs with acute MCAO. Parametric maps were flipped about the axis of symmetry, and CBF and CMRO 2 in the infarcted hemisphere were calculated as percentages of the magnitudes in mirror-image pixels. There were log-linear relationships between the volumes of affected tissue and the percentages of normal CFB or CMRO 2. This graphical analysis showed that the volume of the core deficit was smaller for CBF that for CMRO 2, but expanded more rapidly with decreasing CBF deficit than did the corresponding volumes of reduced CMRO 2. Thus, acute changes in CBF and CMRO 2 following MCAO in the pig can be defined as probabilistic volumes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
