Abstract
Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality. Herbal supplements and diet-based therapies have attracted interest in the treatment of obesity. It is known that Garcinia cambogia (GA) and mulberry leaf, which contain polyphenols, have anti-obesity activity. Herein, we developed a combined tablet consisting of GA extract and bioconverted mulberry leaf extract (BMUL) using a statistical design approach. The ratio and amount of sustained polymers were set as factors. In the cell study, the combination of GA and BMUL showed synergistic anti-obesity activity. In a statistical model, the optimized amounts of hydroxypropyl methylcellulose 2208 (HPMC 2208) and polyethylene oxide 303 (POLYOX 303) were 41.02% and 58.98%, respectively. Additionally, the selected ratio of microcrystalline cellulose (MCC) was 0.33. When the release, hardness, and friability of the GABMUL tablet were evaluated, the error percentages of the response were lower than 10%. This indicates that the GABMUL tablet was successfully prepared.
Highlights
Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality [1]
Here, we developed a combined tablet consisting of Garcinia cambogia extract (GA) and mulberry leaf extract (MUL)
According to Jung et al, bioconverted MUL (BMUL) has improved the ability to decrease fasting blood glucose levels, tolerate glucose, decrease blood HbA1C levels, and increase plasma insulin compared with MUL [11]
Summary
Obesity is a major health concern worldwide, and it is leading to worsening disease morbidity and mortality [1]. It has been reported that a large amount of polyphenols is contained in cocoa, coffee, green tea, mulberry, and garcinia [6,7,8]. A combined strategy of herbal medicine will be an effective strategy for the treatment of obesity. To improve the bioactivity of herbal products, bioconversion techniques have been widely used [9,10]. Bioconversion, such as microbial fermentation and enzyme treatment, has led to the improvement of bioactivity by enhancing the production of active ingredients. It has been reported that BMUL has shown antidiabetic effects in diabetic rats [12]. Here, we used BMUL rather than MUL for further experiment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
