Statistical data presentation: a primer for rheumatology researchers.

Abstract

Statistical presentation of data is key to understanding patterns and drawing inferences about biomedical phenomena. In this article, we provide an overview of basic statistical considerations for data analysis. Assessment of whether tested parameters are distributed normally is important to decide whether to employ parametric or non-parametric data analyses. The nature of variables (continuous or discrete) also determines analysis strategies. Normally distributed data can be presented using means with standard deviations (SD), whereas non-parametricmeasures such as medians (with range or interquartile range) should be used for non-normal distributions. While the SD provides a measure of data dispersion, the standard error provides estimates of the 95% confidence interval i.e. the actual mean in the population. Univariable analyses should be directed to denote effect sizes, as well as test a priori hypothesis (i.e. null hypothesis significance testing). Univariable analyses should be followed up by suitable adjusted multivariable analyses such as linear or logistic regression. Linear correlation statistics can help assess whether two variables change hand in hand. Concordance rather than correlation should be used to compare outcome measures of disease states. Prior sample size calculation to ensure adequate study power is recommended for studies which have analogues in the literature with SDs. Statistical considerations for systematic reviews should include appropriate use of meta-analysis, assessment of heterogeneity, publication bias assessment when there are more than ten studies, and quality assessment of studies. Since statistical errors are responsible for a significant proportion of retractions, appropriate statistical analysis is mandatory during study planning and data analysis.