Abstract
The selection of a solvent system which will give optimum resolution in liquid chromatography is not a simple matter. The most important considerations are the properties of the material being separated and the stationary phase. The mobile phase in liquid chromatography plays an important if not a major role in the separation process. Selection of the mobile phase is based on the properties of the stationary phase, which in turn is chosen after consideration of the properties of the solute mixture to be separated. This chapter deals with methods for selecting an optimum mobile phase for isocratic elution. These methods are based on sound statistical approaches which eliminate operator intuition or guessing and result in savings in time and material. One of the most difficult and time-consuming aspects of searching for a mobile phase that will give optimal separation is the identification of the eluted peaks.
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