Abstract

Worldwide studies evaluated the pre-processing predictors of cellular yield of cord blood units and established the criteria for the selection of the best units for cryopreservation, however similar studies and data in the Middle East is not available yet. Accordingly, the present work was intended to study the maternal, obstetric and neonatal factors affecting volume and cellular content of 308 cord blood (CB) units. In our analysis birth weight was the most effective factor, with significant positive correlation between birth weight and CB volume, total nucleated cells (TNCs), mononuclear cells (MNCs) and CD34+ve cells counts/unit, and significant positive effect in multivariate analysis. There was significant positive correlation between gestational age and TNCs, MNCs/ml however in multivariate analysis gestational age showed significant negative effects on CD34+ cell counts, as each additional week of gestation contributes to a 17.6% decrease in CD34+ cell counts. Maternal age, diabetes, preeclampsia, mode of delivery, and other obstetric factors had no effect on these laboratory parameters. Predicting CB volume and cell content using maternal/neonatal information before cell processing would be beneficial to reduce the cost of collection and processing for cord blood banking.

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