Abstract
To investigate the anticonvulsant effects of Pasipay, a commercially available preparation of hydro-alcoholic extract of Passiflora incarnata in rats.The anticonvulsant effects of hydro-alcoholic extract of P. incarnata, Pasipay, were observed by intracerebroventricular injection of 0.125, 0.25, 0.55 and 1.5 microg Pasipay.Pasipay could dose-dependently affected minimal clonic seizures and generalized tonic-clonic seizures induced by pentylenetetrazole, through increment in seizure onset significantly. Additionally, pretreatment with 5 nmol/L flumazenil could abolish the anticonvulsant effects of Pasipay on the onset of both seizures.The results indicate that Pasipay has anticonvulsant effects in the brain, possibly through positive allosteric modulation of the GABAA receptor complex via interaction at the benzodiazepine site.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
